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Pollution, smoking, lack of sleep, poor diet, and UV exposure all increase oxidative stress

doi: 10.1007/s00125-009-1402-z 47 JoJRAnSGhoshSNedumaranBKimYD

doi: 10.3389/fcell.2021.732820 45 MahajanNAroraPSandhirR

Certain probiotic strains direct mucosal immune activity by inducing the secretion of key cytokines and B-cell growthpromoting factors, including interleukin-4 (IL-4), interleukin-5 (IL-5), and interleukin-13 (IL-13) (215, 244)

Desulfovibrionales have genes for sulfate reduction that reduce sulfate to hydrogen sulfide, which results in enhancing farnesoid X receptor (FXR) in HepG2 cells and followed by CYP7A1 inhibition ( Further evidence linking drug metabolism and gut microbiome is research investigating how tacrolimus (TAC) pharmacokinetics were affected by gut microbiome using in vivo mice models