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A novel Cystatin derived from Trichinella spiralis suppresses macrophage-mediated inflammatory responses

Life Sci (2005) 77(15):183643.10.1016/j.lfs.2005.02.014 97 IsobeCAbeTTerayamaY

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Additionally, the metabolite of cholesterol, 7, 25-dihydroxycholesterol (7, 25-OHC), is dramatically elevated in the plasma of SLE patients and binds to the G protein-coupled receptor (GPCR) EpsteinBarr virus-induced gene 2 (EBI2) in macrophages to alleviate the IFN and ISG response for protecting against SLE progress (118)