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Structure-Guided Design and Synthesis of a Mitochondria-Targeting Near-Infrared Fluorophore with Multimodal Therapeutic Activities

doi: 10.1016/j.bbi.2015.11.017 33 BozicI.SavicD.LavrnjaI

To study the active response of astrocytes to CPZ and the GENUS effect, here we measured the levels of EAAT1 and ALDH1A1 colocalization within GFAP + cells

This accumulation enables it to directly modulate the activity of mitochondria-associated metabolic enzymes, thereby protecting high-metabolism organs (such as the heart) from energy crises