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Serum levels of MMP-9 (ng/mL) and TIMP-1 (ng/mL) were measured with a Luminex liquid suspension chip detection assay (R&D Systems, Minneapolis, MN, USA) in accordance with the instructions provided by the manufacturer

Stressful stimuli are known to alter prefrontal dendritic architecture and neuronal connectivity within the PFC (Liston et al., 2009

Similarly, hypoxia-induced damage in BH4-deficient neurons was prevented when a NOS inhibitor, hemoglobin, or superoxide dismutase plus catalase were present during the hypoxic period [126], suggesting that NOS uncoupling might be involved in deficient energy metabolism