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1,21 Although it is generally accepted that patients receiving ICIs and combination ICIs may experience irAEs affecting multiple organ sites, the exact incidence of concurrent or sequential irAEs in the same patient has not been reported in the kidney cancer population

Subsequently, patients transition to monthly injections of cyanocobalamin or injections every two to three months for hydroxocobalamin

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The P53 protein consists of 393 amino acids and mostly functions as a tetramer, which is the active form for DNA binding and transcriptional activation

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