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Jerne explained the rationale behind his method in his diary in March 1962 as follows: 'Antibody molecules diffusing from a single cell into agar containing red cells and complement should lyse [puncture] a sufficient number of surrounding red cells to produce a visible plaque'(Jerne, 1981)

Single-cell transcriptome analysis defines heterogeneity of the murine pancreatic ductal tree

& Tolkovsky, A

By optimizing physiologic growth hormone release, peptides help shield muscle from the catabolic effects of a caloric deficit