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Clinically, ALI manifests as severe hypoxemia, changes in pulmonary function due to increased alveolar capillary membrane permeability, pulmonary edema, and respiratory failure

Similarly, a study based on swimming exercise for a total of four hours showed an increase in NAD + levels, yet also in this case, no measurements of mitochondrial function were performed 309 , reinforcing the need for more exercise-based investigations to further define how NAD + and mitochondrial homeostasis are perturbed and connected during exercise

However, the precise impact of aberrant SLC25A39 expression on cellular function in cancer remains unexplored, despite its pivotal role as the primary mitochondrial GSH transporter