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While maturing in the thymus, thymocytes encounter steps of selection to ensure the generation of mature T cells with the following characteristics: foreign antigen recognition, self-antigen tolerization, and accurate surface marker expression to perform effector functions

EF24, a structural analog of curcumin, can promote the degradation of cytoplasmic HIF-1, thereby synergistically enhancing the antitumor effects of SOF in vitro and in vivo [50]

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Glucocorticoids focus on inducing eosinophil apoptosis, while cytokine regulators focus on blocking and interference of classical cytokines and related pathways