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Indeed, hypoxia commonly drives acidosis, and acidosis can in turn intensify hypoxia, creating a vicious cycle

Jennerwein MM, Eastman A

109,110 Strategies that target GHR signaling The most successful strategy to date for directly inhibiting GHR function has undoubtedly been peptide receptor antagonists, exemplified by the clinically used GHR antagonist pegvisomant (see below)