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Passive sampling devices enable cumulative exposure evaluation across temporal and spatial scales, providing integrated exposure profiles ( 3 Molecular mechanisms of environmental endocrine disruptors impact on male reproductive health Environmental endocrine disruptors exert their deleterious effects on male reproductive physiology through complex, interconnected molecular pathways that fundamentally disrupt normal cellular processes

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However, the substitution of the chromophore phenol(ate) interacting His148 by Ser148 was required to maintain ratiometric behavior (Lohman and Remington, 2008)