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Future exploration of this pathway may establish PC as a novel antifibrotic agent ( 3.4 Natural product-like compound YX-2102 and its mechanisms YX-2102, a pyrano [2,3-b]pyridine derivative identified through virtual screening from a synthetic in-house library of natural product-like compounds, acts as a highly selective cannabinoid receptor 2 (CB2R) agonist ( In vivo studies demonstrate its efficacy in reducing bleomycin-induced lung injury and fibrosis with manageable toxicity

Interstitial fibrosis further induces ischemia and hypoxia by impairing capillary to tubule diffusion, creating a vicious cycle and exacerbating renal injury (43)

As a master detoxifier and the bodys main endogenous antioxidant, glutathione can bind toxins and help remove them from the body

The main reason: the lack of randomized controlled clinical trials in humans

The antiviral response initiated by M1 macrophage activation, including increased expression of STAT-1, interferon regulatory factor (IRF) 7, and IRF9, also depends on the GSH system [168]