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Cell Stem Cell 25 , 473485.e8 (2019)

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Ultimately, they lead to reduced bone formation and increased bone resorption, culminating in bone loss

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Furthermore, mTORC1 can upregulate fatty acid synthase by activating sterol regulatory element binding protein 1 (SREBP1) [54], which increases the proportion of PUFAs in the cell membrane and reduces the abundance of lipid peroxidation substrates required for ferroptosis [55] (circle marked B in Fig