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Comment: Many commenters reiterated their longstanding recommendation that CMS discontinue the ASC weight scalar, stating that the secondary rescaling process applied to maintain budget neutrality has created an inappropriate and growing payment disparity between ASCs and HOPDs, with ASC reimbursement rates now averaging 50 percent less than HOPD rates for the same procedures despite no evidence of increased differences in capital and operating costs between settings

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In ischemiareperfusion injury models, it preserved vascular integrity and reduced inflammation in organs such as liver, kidney, and lungslikely via endothelial stabilization through the nitric-oxide system