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Taxonomic classification is particularly challenging due to the pronounced morphological similarity, phenotypic plasticity, and frequent hybridization among wild and cultivated species (Das, 2014

doi: 10.1074/jbc.M510644200 54 KimY

Although low serum B12 levels have been associated with increased bone turnover and fracture risk (9) , long-term B12 and folic acid supplementation did not improve bone mineral density (38) , or reduce osteoporotic fracture incidence in elderly individuals with elevated plasma homocysteine levels (39)

J Neuroinflammation 22:39 Yang Y et al (2025) Tumor-associated macrophages remodel the suppressive tumor immune microenvironment and targeted therapy for immunotherapy

Another immunomodulatory microbial metabolite is tryptophan-derived indoles, which activate the aryl hydrocarbon receptor (AhR) on astrocytes and intestinal immune cells [72]