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In contrast, ALA exerts its principal effects on mitochondrial metabolism through its established role as an essential cofactor for mitochondrial -ketoacid dehydrogenase complexes, including pyruvate dehydrogenase and -ketoglutarate dehydrogenase, thereby facilitating efficient entry of glycolytic substrates into the tricarboxylic acid cycle and sustaining electron transport chain activity under oxidative stress conditions

doi: 10.1016/j.tranon.2016.09.009 77 KuoCCWuJYWuKK

By reducing systemic inflammation, the KD may help alleviate pelvic pain and other inflammatory symptoms associated with the disease [11,12,13]

It shows why we should look at both vitamins when we see similar symptoms or lab results

In this model, genes associated with the one-carbon metabolic pathways, including the folate and methionine cycles, are up-regulated in the fungal cells upon infection, and are supposed to result in enhanced biosynthesis of nucleotides, NADPH, glutathione and methyl groups