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127 Copper-induced autophagy can also facilitate cell death in cases of overactivation, particularly through ferroptosis, a form of autophagy-dependent cell death

In the first case, the alkylation of the imide nitrogen of the glutarimide ring is carried out only after the condensation of the glutarimide and phthalimide moieties, under conditions similar to those of the pre-conjugation alkylation (compounds 135 or 136 ) 190

PMID: 40747656

for example, defective mitophagy in fibroblasts is associated with increased cell death, although upregulation of mitophagy is beneficial in reducing ROS-induced damage [69, 70]

doi:10.1038/ng0596-43