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(b) the constitutive activity of GHSR

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The introduction of wortmannin was found to significantly reverse the expression of PI3K and AKT, as well as the anti-apoptotic and anti-inflammatory effects of Dihexa, resulting in a decrease in the number of neuronal cells present in the cortex and the levels of IL-10, and an increase in the levels of TNF-alpha and IL-1-beta [1]

[DOI] [PMC free article] [PubMed] [Google Scholar] 4.Duffield JS, Lupher M, Thannickal VJ, & Wynn TA