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One of these derivatives, deferiprone (3-hydroxy-1,2-dimethylpyridin-4(1 H )-one

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Furthermore, AP attenuated NF-B activation and inhibited the expression of IL-1 and TNF- but did not reverse the level of TLR4, an effect that might be attributed to the suppressive effects of Nrf2 and HO-1 on NF-B (Shen et al., 2024a)

GSH1 activity was determined following ADP formation using a pyruvate kinase-lactate dehydrogenase-coupled assay