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We found that FMT significantly altered the gut metabolite profile in LPS-induced piglets and notably increased the relative abundance of FMN and FAD in the riboflavin metabolism pathway

Most importantly, targeting either GSH with the inhibitor BSO or Nrf2 through an siRNA approach or with the small molecule inhibitor ML385 sensitised resistant MRT cells to cisplatin-induced cell death suggesting that targeting the Nrf2/GSH antioxidant defence pathway may present a novel therapeutic avenue in the design of new treatment strategies for MRT and a means of overcoming chemoresistance

They signal the pancreas to release insulin, slow the rate at which food leaves the stomach, and communicate with the brain to create feelings of fullness

P.PatelR

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