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Moreover, reactive toxic aldehydes among lipid peroxidation products such as 4-hydroxy-2-nonenal (4-HNE) or malondialdehyde (MDA) are confirmed as markers of oxidative stress-induced lipid peroxidation [17, 18]

Acknowledgements The authors would like to thank Nicoleta Decea and Remus Moldovan from the Laboratory of Research in the Oxidative Stress, Physiology Department, Iuliu Haieganu University of Medicine and Pharmacy, for their help in the experimental work

A phenotype-driven approach to generate mouse models with pathogenic mtDNA mutations causing mitochondrial disease

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