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In this context, the main metabolic costs underlying neuronal activity involved not only the maintenance of the glutamate-glutamine cycle, but also the generation and propagation of action potentials, uptake and recycling of neurotransmitters from the synaptic cleft, and restoration and maintenance of resting membrane potential (reviewed in Attwell and Laughlin, + -dependent stimulation of astrocytic metabolism suggests that the actual glial contribution to total energy metabolism has been long underestimated (DiNuzzo et al., This article reviews the biochemical mechanisms associated with energy metabolism in brain cells, and provides a critical review of the traditional view of astrocytes being glycolytic and neurons oxidative, which has been challenged over the past years by evidence pointing to important rates of oxidative respiration in astrocytes, namely during increased brain activity

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Babcock AA, Kuziel WA, Rivest S, Owens T

10.1038/s41598-019-45868-8 62

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