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A dose-dependent decrease in body weight was shown, ranging from -1.3 kg in the placebo group to -1.4 kg in the 0.03 mg/kg leptin-treated group, and to -7.1 kg in the 0.30 mg/kg leptin-treated group (8)

The clinical program failed

Together, they create a synergistic GH pulse that is larger than either compound produces alone and more physiologically similar to the natural nocturnal GH release pattern