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Nature 431 , 9971002, (2004)

Heat and Pressure Resistance of Escherichia coli and Its Inactivation in the Presence of Antimicrobial Compounds

However, futile quinone redox cycling can lead to a cascade of ROS formation and as such, the link between toxicity and quinone redox cycling is widely acknowledged 5

Tier 4 (Mostly anecdote/marketing): Benefits are plausible, but evidence is thin

Aberrant hypermethylation of promoter regions results in gene silencing, either by preventing transcription factor binding or by facilitating the recruitment of repressor complexes, whereas hypomethylation may inappropriately activate normally silenced genes, thereby promoting genomic instability and dysregulated gene expression [110]