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Accumulation of ROS plays a crucial role in the pathogenesis of cardiomyopathy, leading to myocardial fibrosis, ventricular remodelling and direct damage to cardiomyocytes (74)

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By way of these derivatives, Trp is a precursor in the synthesis of serotonin, melatonin, niacinamide, and vitamin B3

Moreover, studies have indicated that the interaction between FOXOs and P53 can modulate aging in yeast and invertebrates (Chen et al., 2022)