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To further explore whether GPX2 has effects on glutathione metabolism and cancer stemness in vivo, we performed analysis of reducing equivalents and immunohistochemical staining

COPZ1 knockdown in glioblastoma cell lines (U87MG, U251, and P3) induces ferritinophagy, upregulates NCOA4, and activates autophagy-related protein ATG7, leading to excessive Fe 2+ release, ROS accumulation, and ferroptotic cell death [36]