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Nat Cancer 1 , 976989 (2020)

TABLE 2 Molecular regulation of circadian clock components by deubiquitinating enzymes

doi:10.1038/nrn4003 97

J Pathol 169(3):341345

Concomitantly, ROS can oxidatively activate Ca 2+ /calmodulin-dependent protein kinase II (CaMKII) via methionine oxidation (e.g., Met281/282 oxidation), producing sustained kinase activity that phosphorylates mitochondrial Ca 2+ handling proteins such as the mitochondrial calcium uniporter (MCU) or its regulatory subunits