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Enhancing delta-wave sleep, DSIP may improve both subjective and objective sleep quality, providing a potential solution for those suffering from chronic insomnia

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Relative contraindications requiring careful consideration and enhanced medical supervision include history of pancreatitis, severe gastrointestinal disease including gastroparesis, diabetic retinopathy (requires ophthalmologic monitoring during therapy), severe kidney disease, history of suicidal ideation or severe depression, gallbladder disease or history of cholecystitis, and age under 18 years

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On the other hand, ER36, a 36 kDa truncated isoform of ER66 located on the cytoplasmic membrane of breast cancer (Lv et al., 2015