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The ability to apply in vivo genetic and/or environmental modulations, such as challenging animals with inflammatory agents in rodent models, could lead to induction of DILI at therapeutic doses, as reviewed by Segovia-Zafra et al

2 Perturbation of the gut-lung axis in COVID-19 The reciprocal communication between the gut and lung, which is mainly mediated by microbial metabolites and toxins translation through blood or lymphatic circulation, is known as the gut-lung axis (Synodinou et al., 2022)