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Abstract Metabolic flexibility describes the ability of cells to respond or adapt its metabolism to support and enable rapid proliferation, continuous growth, and survival in hostile conditions

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Chi-square test was used to compare the differences of image features between different groups

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Furthermore, the evidence remains inconsistent, as the potential benefits of TRT are often accompanied by other iatrogenic effects, including erythrocytosis, benign prostatic hyperplasia, gynecomastia, and an increased risk of prostate cancer [178, 179]