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In clinical practice, most of these patients are labeled as drug allergic without appropriate testing, mainly due to fear of a life-threatening reaction, leading to an overdiagnosis of drug allergy

doi: 10.1016/j.jbc.2022.102183, 129

If used at all, lower doses are recommended in the elderly to reduce the incidence of side effects and maintain age-dependent normal levels of IGF-1

We talked her out of the most aggressive option on the menu

Nat Commun 10:1973 Chapman TL, Heikeman AP, Bjorkman PJ (1999) The inhibitory receptor LIR-1 uses a common binding interaction to recognize class I MHC molecules and the viral homolog UL18