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422 Some studies also showed that HER2 heterogeneity correlated with worse clinical outcomes, 423 and HER2 intra-tumoral heterogeneity could be another potential factor for the resistance to anti-HER2 therapy

Lactate regulation and epigenetic modifications Unlike normal cells, tumor cells continuously refine their metabolic patterns to increase their adaptability to a constantly changing microenvironment characterized by hypoxia, low pH, nutrient scarcity, electrolyte imbalance, and oxidative stress

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Sex, age, and handedness modulate the neural correlates of active learning