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In particular, a linear regression model with four predictors, anthropogenic forcing/linear time trend, the El Nio-Southern Oscillation (ENSO), total solar irradiance (TSI), and volcanic aerosols, is capable of explaining ~7080% of the global mean temperature variance 17,18

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doi: 10.1023/A:1005427919188

This may also regulates the activity of several transcription factors to modulate the expression of proteins such as cytoskeletal, cell-cell junctional components, cell cycle regulators and anti-apoptotic effectors

siRNA-mediated GPX4 knockdown induced ferroptosis in high MYCN cells, which was rescued by Fer-1 (Fig