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B12 deficiency can cause fatigue, weakness, and brain fog, symptoms some people experience during early semaglutide treatment as their body adjusts to reduced food intake

Specifically, alkylation of a C3-amino-quinoline derived precursor, such ascompound8, may be achieved via reductive amination with, for example, triethyl orthoformate in TFA followed by treatment with NaBH 4 to give the corresponding secondary C3-amine derivative (such as N-methyl-C3-amino-quinoline 9)

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The objective response rate was 28.2%