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Rapamycin-induced autophagy ameliorates GSH depletion-induced premature cell senescence It was shown that autophagy activation especially in the presence of an increasing autophagic flux inhibits the senescence of RPE cells 35,36,37,38,39

Lack of vitamin C leads to this process being compromised

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This influence is primarily mediated by the autonomic nervous system (ANS), which regulates various aspects, including gut permeability, regional gut motility, intestinal transit and secretion