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Another possibly beneficial and important effect of DSIP is its importance in withdrawal from opioids, when, together with exogenously administered morphine, it was able to modulate opioid peptidergic systems, and in chronic pain, where the results of the study stated a significant reduction in pain attacks in patients with chronic pain and depressive states

A network-based approach is a powerful framework for studying the organizational structure of complex systems 72

J Pept Res 59:1833 Chen Y, Mant CT, Farmer SW, Hancock RE, Vasil ML, Hodges RS (2005) Rational design of -helical antimicrobial peptides with enhanced activities and specificity/therapeutic index

This may give some readers pause if theyre familiar with lithium as used for psychiatric disorders, namely major depression and bipolar disorder

Naidu MUR, Ramana GV, Rani PU, Mohan lyyapu K, Suman A, Roy P