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Moreover, because circulating LCAC levels often correlate with disease severity, NYHA class, and are reduced by surgical intervention, continued monitoring of a CVD patients metabolome could provide insight into the progression or regression of the disease ( 2+ overload mediated by the acylcarnitines [reviewed by Besides CVD, developing a greater understanding of cellular LCAC pathogenesis will be informative for the disease processes of rare, but often lethal, fatty acid oxidation and carnitine metabolism disorders ( Conclusion This review addressed the existing basic science investigations into the direct effects of the amphiphilic metabolites, LCACs, on cardiac function