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Patients receiving CRRT were divided into 2 groups: (i) those receiving late CRRT once acute kidney injury (AKI) has set in, and (ii) those receiving early CRRT within 24 hours of admission and before development of AKI

If astrocytes are impaired, this breaks down

These nutrient precursors include the amino acids cysteine, glycine, and glutamine, as well as selenium, alpha lipoic acid, selenium, vitamin C, milk thistle extract, and aged garlic

doi: 10.1038/s41386-021-01163-7

The medium was altered from the original formulation by substituting 0.2 M sodium sulfide (NaS) with 0.2 M ascorbic acid as the reducing agent and by supplementing it with additional carbon sources (5 mM each of acetate, propionate, and butyrate)