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Description

Thyroid hormones, particularly triiodothyronine (T3) and thyroxine (T4), are transported across the bloodbrain barrier (BBB) by specialized carriers and are metabolically activated or inactivated by local deiodinase enzymes ( Current therapeutic paradigms focus primarily on pharmacological hormone replacement, most commonly levothyroxine (27)

This phenomenon allows GSH to act as a buffer for copper in the cellular solute

GlutPeroxidase-1GP1 By Jag123 (Public Domain) via Commons Wikimedia 2

Furthermore, sequence analyses identified canonical promoter elements in the upstream regions of each chi gene suggesting that these genes, in principle, are expressed in vitro (Fig