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It is manifested as iron redundancy, polyunsaturated fatty acid (PUFA) peroxidation, and abundant generation of lipid reactive oxygen species (ROS)[13]

Given the limited effective therapies, the treatment of this disease is not ideal and its incidence and prevalence are increasing

Obeticholic acid, a semisynthetic bile acid analog, is an agonist of the farnesoid X receptor, which has anti-inflammatory and antioxidant activities (155)