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Further, the concentration of all pro-inflammatory cytokines started to increase as calving approached and attained the highest values on the day of calving

- Prevents the oxidation (darkening) of existing skin melanin

eNOS uncoupling is caused by deficiency or oxidation of tetrahydrobiopterin, an important cofactor for eNOS action, leading to increased generation of superoxide and decreased NO bioavailability (155)