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Dyclonine and leucovorin promote OPC differentiation while maintaining the OPC pool in a mouse model of adult demyelination To further assess the pro-oligodendrogenic capacity of dyclonine (Sm5) and leucovorin (Sm11) in vivo in the context of myelin pathologies occurring later in life, we used the mouse model of adult focal de/remyelination induced by lysolecithin (LPC) injection into the corpus callosum (Fig