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doi: 10.1016/j.freeradbiomed.2018.02.009 112 WillisBCLieblerJMLuby-PhelpsKNicholsonAGCrandallEDDu BoisRMet al

4,5,9,12,1518 Hyperhomocysteinemia has previously been implicated in neural tube defects, stillbirths, recurrent miscarriages, ocular and skeletal abnormalities, stroke, cerebrovascular disease, arteriosclerotic vascular disease, coronary artery disease, and thrombophilic disease

With combined activation (CagriSema) the effect does not add linearly, but supra-additively , which is why the combination has a stronger clinical result than either component alone