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The elevated level of thyrotropin-releasing hormone in primary hypothyroidism is responsible for the increase in serum prolactin levels and the delayed luteinizing hormone response to the stimulating effect of gonadotropin-releasing hormone, which in turn leads to luteal phase failure in women (124126, 131, 132)

Symptoms may also fluctuate throughout the day, and from one day to the next

10.1093/aje/kwf074 65 LiuZ.WangW.FengN.WangL.ShiJ.WangX

Oxid Med Cell Longev 9:2019 Paroni R, Terraneo L, Bonomini F, Finati E, Virgili E, Bianciardi P, Favero G, Fraschini F et al (2014) Antitumour activity of melatonin in a mouse model of human prostate cancer: relationship with hypoxia signalling