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Thus, prolonged exposure to hyperglycemia (glucotoxicity) may result in beta cell dysfunction and reduce insulin secretion, which could be permanent (111)

These include RVG29-mediated brain-targeting peptides to cross the bloodbrain barrier, pH/ROS-responsive carriers for lesion-specific drug release, and mitochondrial-targeting modules to regulate organelle iron homeostasis, thereby minimizing hematologic toxicity caused by non-specific iron chelation

Psychopharmacology (Berl) 172:145156 Gouzoulis-Mayfrank E, Thelen B, Maier S, Heekeren K, Kovar KA, Sass H, Spitzer M (2002) Effects of the hallucinogen psilocybin on covert orienting of visual attention in humans

10.1016/j.ajog.2025.04.069 22 HeydarnejadA.OstadhosseiniS.VarnosfaderaniS

However, this extract did cause a notable drop in platelet count and minor acute liver injury (692)