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12, 17 This triggers the release and/or production of neurotoxic and proapoptotic compounds such as nitric oxide synthase (NOS)

2A) as hypothesized by Kannan et al

Come illustrano Kojima e Kangawa, 2005 per l'intero sistema della grelina, il recettore occupato attiva la fosfolipasi C (PLC), che libera inositolo trisfosfato (IP3)