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As a key anaplerotic substrate for the tricarboxylic acid (TCA) cycle, glutamine provides carbon and nitrogen for the biosynthesis of proteins, lipids, nucleotides, and non-essential amino acids, while also serving as a precursor for glutamate and glutathione (GSH) to maintain redox homeostasis [223, 224]

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33%) and less likely to yield contaminants (4% vs

doi: 10.1038/s41591-018-0092-9 454 PalmerAKTchkoniaTKirklandJL

High levels of estrogen, especially that of estradiol, before the menopause may be involved in the high energy capacity as well as the control of redox balance in female brain (Figure 1)