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Heme iron has been shown to catalyze oxidative damage to DNA, proteins and lipids through Fenton and Haber-Weiss reactions, which generate ROS (162)

Body-weight and fat-mass changes were reported in diet-induced obese mice

Gastroenterology 101 , 13991408 (1991)

These cytokines upregulate TfR1 and downregulate FTH1, thereby promoting intracellular iron overload and ROS generation, which directly sensitize NPCs to ferroptotic death (50)

Feeling a slight sensitivity in the arm area due to opening vascular access on the injection day or, in very sensitive constitutions, a temporary mild dizziness / metallic taste in the mouth along with the systemic diffusion momentum of the drug falls into the category of fully expected temporary physiological reactions