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Diabetic neuropathy relationship with vitamin B 12 deficiency has prominent importance considering vitamin B 12 deficiency is profoundly common, especially among patients with diabetic neuropathy

They also suggest that a person with CKD should take vitamin B12 supplements if necessary to help improve their clinical outcomes

Thus, an earlier study [31] compared different volumes of NaCl 0.9% injected in the thigh of volunteers and found that volumes of 1 ml and 1.5 ml caused more pain than volumes of 0.5 ml or less

There is also MMA and Homocysteine tests which test secondary metabolites affected by B12 deficiency

For reference, these are the Recommended Dietary Allowances (RDA) for vitamin B12 by sex and age group indicating the daily amount needed for healthy individuals ( Men 1418: 2.4 mcg Men 19+: 2.4 mcg Women 1418: 2.4 mcg Women 19+: 2.4 mcg During pregnancy: 2.4 mcg During lactation: 2.8 mcg SUMMARY The RDA for vitamin B12 for most people is 2.4 mcg per day