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albicans were co-infected, a thicker, denser biofilm with stronger tolerance to harmful stresses was formed on root canal dentin and glass slides, which can increase bone resorption of osteoclasts, inhibit the bone formation of osteoblasts, upregulate inflammatory cytokines such as IL-6 and TNF-, and ultimately increase the severity of dental pulp diseases

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Their high receptor specificity and relatively low toxicity profiles (compared to small molecules or full-length proteins) have made them central to 21st-century drug discovery

as each successive "ionization" of the metal atom is performed, it becomes more unlikely that the next electron can become delocalized since it has to fight against a higher effective nuclear charge relative to the electron before it