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Therefore, ferroptosis sensitivity may depend on the glucose starvation status, the level of intracellular NADPH, KG, or glutamine and extracellular cystine, and the expression level of xCT in each cancer cell [16,26,46,58]

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454 In glaucoma mice, mitophagy may also be downregulated, and the mitophagy marker Rheb was observed to be weakened in the retina, 455 so the damaged mitochondria are difficult to be cleared by mitophagy